(주)제넨셀은 당뇨 증상 완화에 도움을 줄 수 있는 건강기능식품 및 의약품의 개발을 위해

다양한 소재에 대한 연구를 지속적으로 하고 있으며, 이들을 통한 사업화를 추진하고 있습니다.

해당 논문은 경희대학교와 공동연구를 통해 법제 과정을 거침으로써 1-Dehydro-6-Gingerdione을 다량 포함하는

‘증숙생강추출물(GG03)’이 이자의 β-세포에서 KATP 채널 폐쇄를 통해 인슐린 분비를 증가 시킬 수 있음을 입증하였습니다. 

나아가 당뇨 치료제로서의 가능성을 제시한 논문입니다.

이 논문은 국제저명학술지 Nutrients (IF 4.171)에 게재되었으며,

추후 증숙생강추출물의 임상 시험 및 사업화 기초 자료로 활용될 예정입니다.

Abstract

Ginger (Zingiber officinal​e Roscoe) and its active compounds (gingerols, shogaols and paradols) have been reported as having beneficial functions for several diseases, including diabetes. In this study, we revealed that the steaming process could enhance the anti-diabetic potential of ginger. To confirm the anti-diabetic effect of steamed ginger extract (GG03), we assessed pancreatic islets impaired by alloxan in zebrafish and demonstrated anti-hyperglycemic efficacy in a mouse model. The EC50 values of ginger extract (GE) and GG03 showed that the efficacy of GG03 was greater than that of GE. In addition, LC50 values demonstrated that GG03 had lower toxicity than GE, and the comparison of the Therapeutic Index (TI) proved that GG03 is a safer functional food. Furthermore, our data showed that GG03 significantly lowered hyperglycemia in a diabetic mouse model. HPLC was performed to confirm the change in the composition of steamed ginger. Interestingly, GG03 showed a 375% increase in 1-dehydro-6-gingerdione (GD) compared with GE. GD has not yet been studied much pharmacologically. Thus, we identified the protective effects of GD in the damaged pancreatic islets of diabetic zebrafish. We further assessed whether the anti-diabetic mechanism of action of GG03 and GD involves insulin secretion. Our results suggest that GG03 and GD might stimulate insulin secretion by the closure of KATP channels in pancreatic β-cells.

Keywords: steamed ginger extract; diabetes mellitus; 1-dehydro-6-gingerdione; pancreatic islets; KATP channels; zebrafish; mice